In goldfish, intraperitoneal injection of SPX induced anorexia, accompanied by an increase in hypothalamic expression of anorexigenic neuropeptide proopiomelanocortin (POMC), with a simultaneous decrease in orexigenic neuropeptide Y (NPY) and agouti-related peptide (AgRP) [4]. The gene discussed is POMC; the disease is Anorexia.