C3a and C5a can affect chemotaxis of eosinophilia, fibroblasts, macrophages, mast cells, and monocytes to the site of infection and inflammation, C5a alone is responsible for neutrophil recruitment [6], while C4a acts as an effector protein and increases endothelial cell permeability and enhances stress fiber formation [22]. The gene discussed is C5; the disease is infection.