IL4 and myeloid sarcoma: In addition, microglial EV also affect other cell types, e.g., EV from pro-regenerative microglia have been shown to promote oligodendrocyte differentiation [40,89], while EV released by microglia transduced with IL-4 ameliorate the disease outcome in experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis (MS) [90].