INS and obesity due to melanocortin 4 receptor deficiency: In addition, it was demonstrated that the hormones of energy metabolism (e.g., insulin-like peptides (Dilps) (a functional homolog of vertebrate insulin), unpaired2 (a functional homolog of vertebrate leptin), adipokinetic hormone (a functional homolog of vertebrate glucagon)) respond to these dietary interventions in a manner such that obesity comorbidities, e.g., insulin resistance, can be provoked [125].