High intracellular LIF is correlated with lower metastasis-free and recurrence-free survival in nasopharyngeal carcinoma, in which xenograft zebrafish and mouse models reveal that LIF enhances vascular invasion, invadopodia formation, and focal adhesion kinases via suppression of YAP1 [81]. The gene discussed is YAP1; the disease is nasopharyngeal carcinoma.