LIF and female infertility: LIF overexpression in mice leads to a fatal cachexic phenotype with excess bone formation, male absence of spermatogonia, and female absence of a corpus luteum, while LIF-/- mice were relatively normal aside from female infertility (able to be rescued by LIF injections), hippocampal abnormalities, decreased hematopoietic stem cells, and excess olfactory neural cells [53,56].