A very recent study showed that hepsin could cleave STING and suppress STING-mediated type I interferon induction and responses in hepsin-producing prostate cancer cell lines, dependent on the protease activity of hepsin [62], which may lead to increased susceptibility to cancer progression in addition to the vulnerability of hepatocytes to chronic viral infections. The gene discussed is STING1; the disease is Familial prostate cancer.