HPN and hepatocellular carcinoma: By contrast, the higher expression of hepsin was positively associated with renal and hepatocellular carcinoma survival according to the analysis of 530 cases of renal cancer (131 cases of low and 399 cases of high expression) and 370 cases of liver hepatocellular carcinoma (136 cases of low and 234 cases of high expression) (Supplementary Figure S3D,E).