CALCA and multiple sclerosis: Under a theoretical perspective, in line with the described pleiotropic immunomodulatory and neuroprotective properties, as well as its expression in spinal motor neurons and the ameliorative effects described in EAE models, the data here presented might support the hypothesis that CGRP, and related peptides could be involved in Multiple Sclerosis pathogenesis; therefore, the relationship between α-CGRP CSF content and lesion burden might be of interest for further evaluation.