B4GALNT3 and malignant colon neoplasm: When the β4GalNAcT3 gene was knocked down in these colon cancer cells, the decreased expression of the LacdiNAc group on N-glycans of the epidermal growth factor receptor (EGFR) resulted in the inhibition of the phosphorylation of EGFR and its downstream signaling molecules, AKT and ERK, followed by the degradation of EGFR [54].