Here, we characterize, for the first time, Trpm8 expression in mouse prostate epithelium and demonstrate that the Trpm8 protein is abundantly expressed in normal glands, as well as in indolent (Pten-null) and lethal (Pten/Trp53-double null and TRAMP) mouse prostate adenocarcinomas, though not in neuroendocrine tumors. Here, TRPM8 is linked to prostate adenocarcinoma.