Despite the suggested role of TRPM8 in prostate tumorigenesis [17], in a recent publication we have demonstrated a potent and specific pro-apoptotic response in different cellular models of aggressive primary tumors, lymph node and bone marrow metastases, triggered by the combination of TRPM8 agonists with sub-lethal doses of radio-, hormone-, or chemo-therapy [15]. The gene discussed is TRPM8; the disease is urogenital neoplasm.