Thus, because GNE-0723, a GluN2A PAM, reduced the power of low-frequency oscillations within the 12–20 Hz band, it was studied in mouse models of Dravet syndrome (i.e., the Scn1a-KI mouse that carries a heterozygous loss-of-function knock-in mutation causing Nav1.1 haploinsufficiency) and Alzheimer’s disease (the J20 mouse that overexpresses human amyloid precursor protein with the Swedish and Indiana familial AD mutations), whose characterization included aberrant low-frequency power, network hypersynchrony and epileptiform discharges [12]. Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.