More recently, a controlled parallel study in 80 subjects with T2DM and obesity demonstrated that the weekly administration of semaglutide or dulaglutide, two long-acting GLP-1 RAs, caused a substantial (of the order of 20%) and dose-dependent reduction in EAT thickness after 12 weeks, while there was no EAT reduction in the control group taking metformin alone. This evidence concerns the gene GCG and type 2 diabetes mellitus.