MAPT and nervous system disorder: This will achieve an increased accuracy in the diagnosis, prognosis and effective therapies for the clinical management of the wide spectrum of neurological diseases involving misfolded MAPT, Aβ peptides and the related neuronal-enriched fibrillar proteins, and their closely related potential for self-aggregation, as well as the seeding, progression and propagation of neuropathological events [12,35,36,39].