The process of “infection” may involve the non-classical release of infectious protein (e.g., α-syn, beta-amyloid or tau) into the extracellular space; aggregation, which may also occur before release; travel in the interstitial fluid; uptake by selective vulnerable neurons or glial cells; induction of a misfold in the host cell; or repeat and potentiation of this step. The gene discussed is MAPT; the disease is infection.