Strikingly, the down-regulation of Mtx2 inhibited Bak mitochondrial localization in resting glioblastoma cells, while Mtx1 down-regulation inhibited Bak mitochondrial localization under apoptotic conditions [94], and the saturation of isolated mitochondria with anti-Mtx1 antibodies inhibited the MOMP induced by activated Bak [93]. This evidence concerns the gene MTX2 and glioblastoma.