It is also known that, unlike DR4, which is involved only in the initiation of apoptosis, the DR5 receptor can participate in the activation of survival, proliferation, and migration of tumor cells by action on the intracellular signaling pathways involving NF-κ B, PI3K/Akt, MAPK, and JNK [42]. The gene discussed is AKT1; the disease is neoplasm.