66% (n = 81) of patients with PDAC showed ↑ uPAR in neoplastic cells, 82% (n = 100) in tumour-associated stromal cells and 62% (n = 75) in both cell types (p < 0.001). ↑ uPAR in stromal cells associated with development of liver metastases. ↑ uPAR associated with ↓ OS and DFS. Here, PLAUR is linked to neoplasm.