MMP1 and pancreatic neoplasm: For example, Roger et al. showed that the concomitant expression of uPA, MMP-1 and IL1-R1 (the ligand receptor for interleukin alpha (IL1A) and beta (IL1B)) could discriminate PDAC from CP and other pancreatic neoplasms such as ampullary adenocarcinomas and pancreatic neuroendocrine tumours [134].