Examples of plasminogen receptors that participate in lysine-dependent binding interactions include α-enolase (ENO1), cytokeratin 8 (CK8), S100A10, annexin A2 (ANXA2) heterotetramer (AIIt; ANXA2 in complex with S100A10), histone 2B (H2B) and plasminogen receptor KT (Plg-RKT), all of which are upregulated in cancer. The gene discussed is ANXA2; the disease is cancer.