ENO1 and neoplasm: Yin et al. found ENO1 overexpression positively correlated with disease stage in the tumour tissue and peripheral blood of patients with PDAC, as well as demonstrating an improved diagnostic sensitivity of the combination of ENO1 and CA19-9 (up to 95%) to detect PDAC, relative to either CA19-9 (70–84.5%) or ENO1 (75.8%) alone [156].