↑ uPA (p = 0.004) and uPAR (p = 0.025) in PC tissue relative to adjacent uninvolved pancreatic tissue. ↑ uPA, uPAR, and PAI-1 in PC tissue independently correlates to a ↑ UICC stage (p < 0.001). ↑ uPAR correlates to ↓ survival following surgery (p = 0.03). ↑ PAI-2 (46%) associated with ↑ survival (p < 0.007) and ↓ tumour size (p = 0.008). The gene discussed is SERPINE1; the disease is neoplasm.