To our knowledge, Plg-RKT expression has not yet been described in any pancreatic cancer models; however, given the strong involvement of macrophages in the tumorigenesis and progression of PDAC and coupled with the high expression of Plg-RKT in macrophages, an investigation into the expression of Plg-RKT in PDAC merits attention. This evidence concerns the gene PLG and familial pancreatic carcinoma.