The study also showed upregulation of ANXA2 in vitro in a gemcitabine-resistant pancreatic cancer cell line (GEM-MIA PaCa-2), where the inhibition of ANXA2 increased the cytotoxic effect of gemcitabine, suggesting its potential role in inducing gemcitabine resistance. Here, ANXA2 is linked to familial pancreatic carcinoma.