Diaz et al. revealed ANXA2 as a specific tPA receptor on the surface of pancreatic cancer cells, demonstrated by co-immunoprecipitation of ANXA2 with tPA in two pancreatic cancer cell lines (Panc-1 and SK-PC-1 cells) alongside co-immunolocalization in tumours. This evidence concerns the gene PLAT and familial pancreatic carcinoma.