uPA ↑ 7.6-fold, uPAR ↑ 9.6-fold and PAI-1 ↑ 3.3-fold in PDAC tissue relative to adjacent uninvolved pancreatic tissue. From 15 genes from 3 gene families, PAI-2 was an independent prognostic marker for improved survival for patients with PC (p = 0.006), more significant than UICC stage (p = 0.012). Here, SERPINE1 is linked to pachyonychia congenita.