RHO and neoplasm: Phosphorylation of Tyr23 was found essential for the cell surface localisation of ANXA2 on PDAC tumour cells and was required for the tumour cells to undergo transforming growth factor (TGF) β-induced and Rho (small GTPases)-mediated epithelial-to-mesenchymal transition (EMT), and ANXA2 knockout or a mutation at Tyr23 in a mouse model of pancreatic cancer inhibited liver metastasis [177].