Plasmin also activates a number of ECM-associated latent growth factors such as the insulin growth factor (IGF [96]), hepatocyte growth factor (HGF [97]), tumour necrosis factor alpha (TNF-α [98]) and vascular endothelial growth factor (VEGF [99,100]) that facilitate tumour cell proliferation and migration and have also been found to promote angiogenesis and lymphangionesis [48,99,100,101,102]. This evidence concerns the gene HGF and neoplasm.