SERPINE1 and cancer: Smith et al. found a positive correlation between tumour PAI-1 mRNA expression and primary tumour size, whereas a negative correlation was seen for PAI-2 expression [112] Across a panel of different cancer types, genomic alterations of SERPINB2 were commonly observed in resected PDAC patients (42% of 109 patient samples), notably a frequent deletion of the gene, alongside increased mRNA expression of PLAU, the gene encoding uPA [122].