↑ uPAR in tumour tissue and ↑ circulating levels of suPAR in PDAC patients relative to healthy controls. ↑ suPAR levels associated with ↑ risk for acute kidney injury and surgical complications post-resection. ↑ pre-operative suPAR serum levels >5.956 × 10−6 g/L associated with ↓ patient OS of 231 days following resection vs. 756 days for patients with suPAR serum levels <5.956 × 10−6 g/L (p = 0.001). Postoperative suPAR serum levels are unsuitable for the prediction of OS. This evidence concerns the gene PLAUR and neoplasm.