Jakubiak GK et al., in a review of the literature, about the current state of knowledge of mechanisms and the clinical significance of restenosis and in-stent restenosis (ISR), in patients with diabetes and PAD, reported an association between an elevated postoperative high-sensitivity C-Reactive Protein (hs-CRP) level, associated with an increased risk of ISR in one-year follow-up in patients who have undergone angioplasty [26]. The gene discussed is CRP; the disease is peripheral arterial disease.