Overall, the expression of these molecules during malaria, either at the onset of infection when triggering the inflammatory response such as suPAR and PTX3, or resulting later from an acute inflammatory response such as sICAM-1 and sEPCR, is associated with the pathogenesis of severe malaria in which the site of initiation of this response and its intensity may play a major role. The gene discussed is PTX3; the disease is malaria.