In this study, we assessed in a cohort of 339 Beninese children presenting with various clinical manifestations of malaria, the level of four soluble receptors (suPAR, sEPCR, sICAM-1 and sTie-2 with its ligand protein Ang-2) and two other bioactive molecules including PTX3 and the calcitonin-precursor-hormone procalcitonin (PCT). This evidence concerns the gene ANGPT2 and malaria.