Interestingly, we found that the levels of suPAR, sICAM-1, sTie-2, Ang-2, PTX3 and PCT were associated with coma and that sEPCR, sICAM-1, suPAR, sTie-2, Ang-2 and PTX3 were associated with fatality. This evidence concerns the gene ANGPT2 and Coma.