Our findings show that in Beninese children with malaria, the levels of suPAR, sICAM-1, sEPCR, sTie-2, Ang-2, PTX3 and PCT differentiate children with SNCM and CM from children with UM, with PCT and sTie-2 providing the highest diagnosis performance for severity with an AUC of [0.83] and [0.78], respectively. Here, ANGPT2 is linked to malaria.