Additionally, Kim et al. found that nuclear SSBP2 expression was associated with tumor multifocality, higher histological grade, vascular invasion, and higher Ki-67 proliferation index, and they also reported that nuclear SSBP2 expression was significantly correlated with poorer OS and RFS in patients with hepatocellular carcinoma [13]. This evidence concerns the gene SSBP2 and hepatocellular carcinoma.