Negative nuclear SSBP2 expression was significantly correlated with larger tumor size (p < 0.001, chi-squared test), higher histological grade (p = 0.016, Cochran–Armitage trend test), higher pT stage (p < 0.001, Cochran–Armitage trend test), ER status (p < 0.001, chi-squared test), and molecular subtype (p < 0.001, chi-squared test). The gene discussed is SSBP2; the disease is neoplasm.