The univariate Cox regression analysis for OS showed that histological grade (p = 0.002), pT stage (p = 0.01), ER status (p = 0.009), lymph node metastasis (p = 0.002), and SSBP2 expression (p = 0.016) were significantly associated with OS. Here, ESR1 is linked to metastatic malignant neoplasm in the lymph nodes.