Chung et al. reported that loss of nuclear SSBP2 expression was observed in 34.3% of colorectal adenocarcinoma (CRA) and 76.3% of metastatic CRA cases, and they noted that loss of nuclear SSBP2 expression was associated with higher pT stage, vascular invasion, and poorer OS in CRA [15]. Here, SSBP2 is linked to colorectal adenocarcinoma.