In fact, several studies seem to demonstrate a role of cisplatin-based therapeutic regimens in the induction of PD-L1 expression in HNSCC [23,24,25], while other studies have recently highlighted that radiotherapy could deeply affect the tumor microenvironment and the immune response against tumor also influencing the expression of PD-L1 (abscopal effect) [26]. Here, CD274 is linked to head and neck squamous cell carcinoma.