The results show that age (>60 years, OR = 2.491, 95% confidence interval (CI): 1.184–5.241, p = 0.014), CRP (OR = 1.007, 95% CI: 1.004–1.010, p < 0.001), blood sugar (OR = 1.007, 95% CI: 1.004–1.011, p < 0.001), and DM (OR = 4.017, 95% CI: 1.764–9.148, p < 0.001) were significant risk factors for CNF. The gene discussed is CRP; the disease is congenital nephrotic syndrome, Finnish type.