A study by Younossi et al., who analysed the phosphoproteome of the liver, as well as the serum proteome in NAFLD patients with or without NASH, identified 74 differentially expressed proteins (DEPs), which mostly belong to three phosphorylated signalling pathways: the phosphoinositide 3-kinase PI3K/AKT, the epidermal growth factor receptor (EGF/EGFR) and the apoptosis signal-regulating kinase 1 (ASK1)-MAPK signalling pathway [275]. This evidence concerns the gene MAP3K5 and metabolic dysfunction-associated steatotic liver disease.