Amongst the differentially expressed phosphoproteins, Tyk2 and ALDH were found to be independent predictors for NASH, whereas the combined proteome profiling of liver and serum identified that hepatic ASK1 S38 and p38 MAPK, as well as serum α2M and coagulation factor V, were associated with collagen deposition in patients with NASH, indicating an association with liver fibrosis [275]. This evidence concerns the gene A2M and metabolic dysfunction-associated steatohepatitis.