Several inflammatory markers have been considered as circulating biomarkers for the diagnosis of NASH and fibrosis, including C-reactive protein (CRP), tumour necrosis factor (TNF), interleukin-8 (IL-8) and C-X-C Motif chemokine ligand 10 (CXCL10). The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.