Increased levels of total plasminogen activator inhibitor, activated plasminogen activator inhibitor 1 (aPAI1), IL-8 and soluble interleukin-1 (IL-1) receptor 1 were found to be raised in NASH, but only aPAI1 has been found to be significantly associated with a diagnosis of NASH in a recent study by Ajmera et al. [51]. This evidence concerns the gene CXCL8 and metabolic dysfunction-associated steatohepatitis.