TOP2A and neoplasm: It was found that the presence of a deletion in the TYMS gene and amplification in GSTP1 are factors that increase the risk of tumor metastasis (HR = 0.17; 95% CI: 0.02–1.03, p = 0.05 and HR = 0.48; 95% CI: 0.11–2.08, p = 0.04, respectively), whereas TUBB3 deletion, on the contrary, caused a low risk of metastasis (HR = 5.31; 95% CI: 0.99–28.36, p = 0.05), as well as a high level of TOP2α gene expression (HR = 3.29; 95% CI: 1.15–9.41, p = 0.02), (Table 4).