In fact, in contrast to adult gliomas, pediatric, especially iHGG (especially those arising in children younger than 1 year), share a common genetic feature represented by the presence of receptor tyrosine kinase (RTK) alterations, harboring fusions in ALK, ROS1, NTRK1/2/3, and MET genes, reported in almost 61–83% of cases [34]. This evidence concerns the gene ROS1 and central nervous system cancer.