Their expression in breast cancer has been investigated using cell lines, animal models, and human tissue samples, and correlated with patients’ prognosis [19,23,24,25,26,27,28,29,30] EPHA2, EPHB4, and EPHB6 are the receptors most extensively studied so far [15,17,18,20,28,31]. This evidence concerns the gene EPHB4 and breast carcinoma.