Hemangioendothelioma could instead give more trouble, but clinical data, as younger age at presentation, female predilection, and multivisceral involvement, could avoid misdiagnosis, associated with the expression of vascular markers, such CD31, CD34 and Factor VIII positivity, accompanied by negativity for mesothelial markers, such as WT1 and calretinin [31]. This evidence concerns the gene PECAM1 and hemangioendothelioma.