Moreover, Chen et al. reported that serum HMGB-1 concentrations are elevated in severe COVID-19 patients, and exogenous HMGB-1 induces the expression of the SARS-CoV-2 entry receptor for angiotensin-converting enzyme-2 in alveolar epithelial cells in a RAGE-dependent manner [8]. Here, ACE2 is linked to COVID-19.