PYGL and neoplasm: Among these eQTL, the most significant eQTL were associated with eGene PYGL, the glycogen phosphorylase evolved in glycogen metabolism induced by hypoxia in solid tumors [20], and HLA-B, one of the human leukocyte antigen class I molecules whose expression is associated with tumor stage and the survival of CRC [21] (Figure 2A,B).