The transcripts coding for proteins implicated in glutathione generation and function (gamma-glutamyl cysteine ligase, glutathione reductase), antioxidant systems (superoxide dismutase 2; SOD2), and thiol-disulfide interaction (glutaredoxin) were identified in the mouse model of HD, suggesting that the restoration of sensitive-cysteine redox homeostasis plays a critical role in neuroprotection (Figure 1 and Figure 2). The gene discussed is GLRX; the disease is Huntington disease.