A few combination therapies such as ubiquinol and ascorbic acid [200], lycopene with vitamin E [201], CoQ10 and Omega-3 [202], and resveratrol and curcumin [203] reported to having a synergistic beneficial effect on reducing amyloid plaques and tau hyperphosphorylation in transgenic or sporadic models of AD. The gene discussed is MAPT; the disease is Alzheimer disease.