Among them, hypermethylation-associated downregulation of cystine-glutamate antiporter SLC7A11 gene [164], elevation of lipid peroxidation products [165], increased iron concentrations and decreased GPX4 activity in substantia nigra [166,167], and DJ-1 depletion rendering neurons susceptible to the ferroptosis [168] are evident in PD models and are clearly linked to PD pathogenesis. Here, GPX4 is linked to Parkinson disease.