SOD1 and cardiomyopathy: Additionally, in vivo studies demonstrate that supplementation of EGCG to streptozotocin-nicotinamide-induced diabetic rats with cardiomyopathy not only markedly mitigates ROS-mediated lipid peroxidation, inflammatory cytokines, fibrosis, and cell death, but also significantly enhances the antioxidant activity of SOD and CAT [15,16].