Additionally, the anti-angiogenic effect of quercetin has been closely linked to the decrease of VEGF-A, MMP2, and MMP9 expression [48], as well as to the inhibition of both tumor growth and angiogenesis by targeting VEGFR2 regulated by AKT/mTOR/P70S6K signaling pathway [49]. Here, AKT1 is linked to neoplasm.