AKT1 and neoplasm: It has been reported that inflammatory factors contribute to the development of HCC tumor growth; interestingly, quercetin has shown the capability to decrease inflammation by inhibiting proinflammatory pathways, such as that of NF-κB and COX-2 in a human hepatoma cell line, and also by regulating PI3K/Akt and JNK activation [38,39]; these could be some of the possible molecular mechanisms by which quercetin inhibits the preneoplastic lesion growth.