HMOX1 and acute kidney injury: In cisplatin-induced AKI, miRNA140-5p favors Nrf2 regulation by a mechanism independent of Keap1, promoting the increase in heme oxygenase 1 (HO-1), NAD(P)H quinone oxidoreductase (NQO1), and manganese SOD (MnSOD), which leads to decreasing ROS and attenuating oxidative stress [47].