In this study, we also investigated the changes in plasma levels of obesity-associated factors, including leptin, ghrelin, glucose, insulin, gastric inhibitory polypeptide, and pro-inflammatory cytokines levels, as well as the lipid profile, including HDL, LDL, FFA, TG, and TC, when the atherogenic index was calculated. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.