In addition, genistein is also a potent inhibitor of angiogenesis, and several mechanisms have been reported, both in endothelial and cancer cells, to be responsible for this activity, including the inhibition of protein tyrosine kinase activity and MAPK activation in VEGF-stimulated endothelial cells [118,123,125] and the inhibition of HIF-1 in pancreatic carcinoma cells [118,125,126] (Figure 4). This evidence concerns the gene VEGFA and cancer.