PRKN and Parkinson disease: The role of Lewy bodies in Parkinson’s disease pathogenesis is controversial since it has been proposed to play key role in the propagation of the disease from one to another region [35]; on the other side, the formation of Lewy bodies is not required to induce two familial forms of Parkinson’s disease, because patients with LRRK2 and parkin mutation do not develop Lewy bodies [57,58].