In the case of 14-3-3ζ/δ, Yu et al. [54] reported that immune-associated genes involved in interferon signaling, TLR-4 signaling, inflammasome network, antigen presentation/TCR recognition, and CD28 co-stimulation were found significantly downregulated in patients with urothelial carcinomas of the urinary bladder (UCUBs) presenting YWHAZ amplification/overexpression. This evidence concerns the gene CD28 and bladder transitional cell carcinoma.