Considering that: (1) YWHAZ has been reported to be an independent and strong predictor of aggressiveness in PCa [38]; (2) its expression showed a significant negative correlation with HMOX1 expression; (3) PCa patients with high YWHAZ/HMOX1 showed the highest HR; and (4) high YWHAZ was the only factor significantly associated with a higher risk of relapse; we validated the interaction between HO-1 and 14-3-3ζ/δ. Here, HMOX1 is linked to posterior cortical atrophy.