NFE2L2 and psoriasis vulgaris: In addition, the investigators concluded that, apart from an elevation in oxidative stress levels in the two aforementioned ailments, the expression of nuclear erythroid factor 2-related factor 2 (Nrf2) and the cannabinoid receptor type 2 was raised in patients with psoriasis vulgaris only, indicating that antioxidant and anti-inflammatory systems are overactive in these subjects [25].