A conundrum of research endeavors which collected venous blood samples from individuals suffering from psoriasis with variable duration of the disease detected low levels of total antioxidant status [37,38,46,47,51,54,63,64] and alterations in enzymes involved in decreasing free oxygen radicals concentrations, i.e., catalase [21,22,39,40,47,54,61], superoxide dismutase [39,47,54,61,63,65], paraoxonase-1 [15,23,39,43,50,51] and glutathione peroxidase [25,63]. The gene discussed is CAT; the disease is psoriasis.