Balta et al. also observed lower levels of total bilirubin (p < 0.05), direct bilirubin (p < 0.001) and higher levels of indirect bilirubin (p < 0.05) and CRP (p < 0.001) in this dermatosis, emphasizing once again the association between total bilirubin, atherosclerosis and cardiovascular diseases (as systemic complications of psoriasis), as these subjects display an elevated carotid intima-media thickness [41]. The gene discussed is CRP; the disease is skin disorder.