The growing body of evidence from both in vitro and in vivo studies indicates that α- and β-asarone exert neuroprotective effects by inducing NTF expression and/or potentiating NTF functions, besides their anti-apoptotic, and anti-inflammatory activities, and thus might have potential in the treatment of neurodegenerative diseases, such as AD and PD. Here, TNF is linked to Alzheimer disease.