Enzyme-linked immunosorbent assays and immunohistochemistry analyses revealed that the β-asarone-mediated activation of MEF2D reduced the loss of TH-positive neurons in the mesencephalon, restoring nigrostriatal neuronal morphology in 6-OHDA-induced mouse models of PD [29], indicating that β-asarone can stimulate the activity of MEF2D via chaperone-mediated autophagy. Here, TH is linked to Parkinson disease.