A recent study showed that β-asarone treatment protected against 6-OHDA-induced dopaminergic neurodegeneration in a rat model of PD through the downregulation of JNK and p-JNK expression, resulting in the indirect increase in Bcl-2, accompanied by improved behavioural performance in the open-field and rotarod tests, as well as improved movement initiation and stepping time [89]. This evidence concerns the gene MAPK8 and Parkinson disease.