Since lactate, through the activation of the GPR81 receptor, promotes tumor proliferation and wound healing, and the switch towards the oxidative phenotype in MDA-MB-231 cells, and given the stimulation of IGFBP6 production after exposure to lactate or an antagonist, and vice versa, we evaluated the effect of direct exposure to IGFBP6 on the expression of the genes involved in the pathway of mitochondrial metabolism, and on the proliferation of the cells under examination. Here, IGFBP6 is linked to neoplasm.