In two models of atherosclerosis, ApoE−/− mice with high-fat diet and ApoE−/− mice with high-fat and high-methionine diet, the levels of IL-1β and IL-18, macrophage infiltration and atherosclerotic lesions were increased compared with control mice, while the silencing of NLRP3 gene reduced all of these effects [32]. This evidence concerns the gene APOE and atherosclerosis.