IL1B and endothelial dysfunction: Similarly to MCC950, Ang-(1-7), the protective heptapeptide of the renin-angiotensin system, and the anti-aging protein klotho can equally inhibit the endothelial priming and activation of the NLRP3 inflammasome induced by IL-1β, thus preventing endothelial cell senescence in vitro and endothelial dysfunction in vivo [53].