SOD1 and ablepharon macrostomia syndrome: Regarding antioxidant treatment, a recent study with mice demonstrated that pretreatment with 5,6,7,8-tetrahydroxyflavone (5,6,7,8-THF), which has antioxidant properties, increased the activity levels of SOD, CAT, and GSH-Px and decreased the H2O2 and MDA contents in the brain and heart, indicating that the use of this flavone as an excellent antioxidant enhancer, lipid peroxidation inhibitor, and general anti-hypoxia agent for preventing AMS merits further exploration [35].