HMOX1 and lung adenocarcinoma: Podder et al. demonstrated that EA treatment could attenuate ROS production but increase heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO1) expression through activating the Nrf2 signaling pathway in paraquat (PQ)-induced human lung adenocarcinoma A549 cells [20].