Moreover, in the deoxycorticosterone acetate (DOCA)/salt-induced hypertension model, the levels of the 32-residue hormone peptide ELABELA are decreased, promoting the activation of NOXs that generates ROS, and subsequently, NLRP3 inflammasome activation in the renal medulla and renal cortex (Table 5) [242]. Here, NLRP3 is linked to hypertensive disorder.