Zhao and group discovered that decreasing NLRP3 recruitment and subsequent caspase-1 activity by blocking P2 × 7R, decreased glomerular damage in MRL/LPR mice with lupus nephritis, lowering serum anti-dsDNA antibody level, as well as IL-1β and IL-17 levels [216]. This evidence concerns the gene NLRP3 and lupus nephritis.