Mice lacking NLRP3 or ASC were reliably protected from oxalate-induced kidney fibrosis without compromising oxalate equilibrium, implying that NLRP3/ASC/caspase-1/IL-1β/IL-18 are vital factors involved in the pathophysiology of oxalate-induced CKD [18,218]. The gene discussed is IL1B; the disease is chronic kidney disease.