The NLRP3 inflammasome was implicated in the pathogenesis of multiple kidney diseases, such as adenine-induced tubulointerstitial nephritis [203], metabolic syndrome-associated nephropathy [204,205], hyperhomocysteinemia-induced glomerulosclerosis, proteinuria-induced tubular injury [206], angiotensin II-induced hypertensive kidney injury [207], and diabetic kidney disease (DKD) [208]. This evidence concerns the gene NLRP3 and hyperhomocysteinemia.