Moreover, it has been widely demonstrated that the expression of several NRF2-dependent genes is increased in PD brains (i.e., heme oxygenase 1 (HMOX1), glutamate-cysteine ligase regulatory subunit (GCLM), sequestosome-1 (SQSTM), and NAD(P)H:quinone oxidoreductase 1 (NQO1)) [18,19,20,21,22]. This evidence concerns the gene NFE2L2 and Parkinson disease.