NFE2L2 and hypertrophic cardiomyopathy: In addition, in several models of hypertrophic cardiomyopathy, the overexpression of NRF2, including its target genes (Hmox1, Gpx1, Txnrd1, Nqo1, and Sod2: mitochondrial), significantly reverses LV remodeling and fibrosis (reviewed by [20]).