NFE2L2 and obesity due to melanocortin 4 receptor deficiency: The pharmacological activation of NRF2 using the synthetic triterpenoid CDDO-Im (2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide) results in the prevention of high fat diet (HFD)-induced obesity in mice models, as reviewed in detail by Mimura and Itoh [21].