Zeng et al. evaluated the role between NF-κB and NRF2, and the ability of curcumin to prevent these cardiac alterations induced by obesity, using an in vitro model in cardiac H9C2 cells exposed to palmitate and an in vivo model of HFD-fed male mice. This evidence concerns the gene NFKB1 and obesity due to melanocortin 4 receptor deficiency.