However, the deletion of Nfe2l2 in adipocytes led to a worsened systemic metabolic phenotype (increased glucose, cholesterol, and non-esterified fatty acids levels), whereas the deletion of Nfe2l2 in hepatocytes modestly reduced insulinemia after long-term HFD-induced obesity in mice [63]. This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.