Furthermore, NRF2 expression and activity were induced in response to oxidative stress, recruiting NRF2 to the Srebf1 (sterol regulatory element binding transcription factor 1) promoter, which induces target gene transcription and subsequent lipogenesis, thus promoting lipid accumulation in adipocytes and exacerbating the development of obesity. Here, NFE2L2 is linked to obesity due to melanocortin 4 receptor deficiency.