NFE2L2 and Hyperglycemia: Moreover, diallyl trisulfide which is a powerful antioxidant among the sulfur-containing compounds of garlic oil, increased NRF2 protein stability and nuclear translocation, protecting against hyperglycemia-induced ROS-mediated apoptosis by upregulating the PI3K/AKT1/NRF2 pathway in cardiomyocytes exposed to high glucose [77].