Interestingly, as reviewed in detail by Chen and Maltagliati, several functional Nfe2l2 polymorphisms are associated with risk of human cardiovascular disorders, for example, rs6721961 is a C-to-A transversion at −650 nt location and results in diminished ARE activity in the Nfe2l2 gene promoter [19]. The gene discussed is NFE2L2; the disease is cardiovascular disorder.