However, male Nfe2l2-deficiency in ApoE-KO mice, a model of atherosclerosis not associated with obesity, showed less atherosclerotic lesions only at late stages; this finding could be related to regulatory effects of NRF-2 on lipid metabolic genes [115,116,117]. This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.