In cardiac tissue with steatosis from a mouse NASH model induced by a high-fat/high-carbohydrate diet, we found elevated NRF2 protein levels, and the treatment with prolonged-release pirfenidone overexpressed PPARA and PPARG proteins, while NRF2 protein was decreased, thereby improving myocardial steatosis, hypertrophy, and fibrosis induced by obesity [87]. Here, NFE2L2 is linked to metabolic dysfunction-associated steatohepatitis.