In this study, cytokines TNF, IL-6, IL-10, IFN-γ, IL-27, alarmins Hsp72 and Hsp90, and markers associated with inflammation (CRP, procalcitonin, lactate) and stress (glucose) exhibited early-onset induction, which was strongly correlated with an increased TOS/TAC ratio in sepsis. The gene discussed is IL27; the disease is Sepsis.