HMOX1 and Parkinson disease: Furthermore, the mRNA levels of NRF2 target genes, including GSTP1, GSTM1 and heme oxygenase-1 (HO-1), are reduced in D117E- and Q141H-expressing 293T cells compared with cells expressing wild-type NRF2, and these NRF2 variants are proposed to be associated with the pathogenesis of Parkinson’s disease in Chinese populations [71].