The researchers report both oxidative stress-induced tau phosphorylation and tau-induced oxidative stress as contributors to the development of AD due to factors, including reductions in cytoplasmic SOD1 and mitochondrial SOD2, which increases the profile of tau phosphorylation and the induction of mitochondrial dysfunction, resulting in H2O2 production by hippocampal tau phosphorylation, respectively [237,238,239,240]. Here, SOD1 is linked to Alzheimer disease.