Antioxidants that have been explored in combination with other compounds in both cellular and animal models of AD including but not limited to ebselen and donepezil [409], lipoic acid and donepezil [410], ferulic acid and tacrine (the first AChE inhibitor approved for AD, but now discontinued) [411], and polyphenolic hybrids [412,413]. The gene discussed is ACHE; the disease is Alzheimer disease.