Oxidative stress is reported to contribute to other hypotheses of AD, which implicate the aggregation of intracellular tau, elastin degradation, N-methyl-d-aspartate receptor (NMDAR)-mediated cell stress and abnormal extracellular amyloid accumulation as the primary cause [210,211,212,213,214,215,216,217,218,219,220,221]. The gene discussed is MAPT; the disease is Alzheimer disease.